ホームお知らせ研究会について入会案内医療従事者リスト患者友の会研究業績FAQお問い合わせ→English
    • RESEARCH ACHIEVEMENTS
    研究業績

    1. Evaluation of the benefits of neutral bicarbonate ionized water baths in an open‐label, randomized, crossover trial
      Ryoko Ushikoshi‐Nakayama, Tomoe Yamazaki, Daisuke Omagari, Naoyuki Matsumoto, Hiroko Inoue, Chiyoko Nukuzuma, Seiji Nishino & Ichiro Saito
      Sci Rep. 2024 Jan 13;14(1):1261. doi:10.1038/s41598-024-51851-9
      https://www.nature.com/articles/s41598-024-51851-9.pdf

    2. Reliability of non-contact tongue diagnosis for Sjögren's syndrome using machine learning method
      Noguchi K., Saito I., Namiki T., Yoshimura Y., Nakaguchi T.
      Sci Rep. 2023 Jan 24;13(1):1334. doi: 10.1038/s41598-023-27764-4.

    3. Effects of polyphenols in non-centrifugal cane sugar on saliva secretion; in vitro and in vivo experiments and a randomized controlled trial
      Shakya S., Ushikoshi-Nakayama R., Yamazaki T., Omagari D., Aota K., Inoue H., Matsumoto N., Saito I.
      J Clin Biochem Nutr. 2022 Dec 28, doi:10.3164/jcbn.22-114

    4. Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication
      Tanaka J., Senpuku H., Ogawa M., Yasuhara R., Ohnuma S., Takamatsu K., Watanabe T., Mabuchi Y., Nakamura S., Ishida S., Sadaoka T., Takaki T., Shirota T., Shimane T., Inoue T., Sakai T., Mori M., Tsuji T., Saito I., Mishima K.
      Nat Cell Biol. 2022 Nov;24(11):1595-1605. doi: 10.1038/s41556-022-01007-6. Epub 2022 Oct 17.

    5. Endoplasmic reticulum stress affects mouse salivary protein secretion induced by chronic administration of an α1-adrenergic agonist
      Yoshino Y., Imamura T., Yamachika S., Ohshima T., Ushikoshi-Nakayama R., Inoue H. Saito I., Nakagawa Y.
      Histochem Cell Biol. 2022 Apr;157(4):443-457. doi: 10.1007/s00418-021-02047-z. Epub 2022 Jan 17.

    6. The effects of bathing in neutral bicarbonate ion water
      Yamazaki T., Ushikoshi-Nakayama R., Shakya S., Omagari D., Matsumoto N., Nukuzuma C., Komatsu T., Chang-il LeeM., Inoue H., Saito I.
      Sci. Rep. 2021 Nov 8;11(1):21789. doi: 10.1038/s41598-021-01285-4.

    7. Hyperglycemia Induces Generation of Reactive Oxygen Species and Accelerates Apoptotic Cell Death in Salivary Gland Cells
      Matsumoto N., Omagari D., Ushikoshi-Nakayama R., Yamazaki T., Inoue H., Saito I.
      Pathobiology, 2021;88(3):234-241. doi: 10.1159/000512639.

    8. FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cystic formation in salivary gland
      Isono Y., Furuya M., Kuwahara T., Sano D., Suzuki K., Jikuya R., Mitome T., Otake S., Kawahara T., Ito Y., Muraoka K., Nakaigawa N., Kimura Y., Baba M., Nagahama K., Takahata H., Saito I., Laura S. Schmidt, W. Marston, Linehan, Kodama T., Yao M,. Oridate N., Hasumi H.
      Biochem. Biophys. Res. Commun., 2020 Feb 19;522(4):931-938. doi: 10.1016/j.bbrc.2019.11.184. Epub 2019 Dec 2.

    9. Evaluation of the effect of a heat-killed lactic acid bacterium, Enterococcus faecalis 2001, on oral candidiasis
      Yamazaki T., Ushikoshi-Nakayama R., Shirone K., Suzuki M., Abe S., Matsumoto N., Inoue H., Saito I.
      Benef Microbes. 2019, 10 (6): 661-669. doi: 10.3920/BM2018.0115. Published Online: July 03, 2019.

    10. Effect of gummy candy containing ubiquinol on secretion of saliva: A randomized, double-blind, placebo-controlled parallel-group comparative study and an in vitro study
      Ushikoshi-Nakayama R., Ryo K., Yamazaki T., Kaneko M., Sugano T., Ito Y., Matsumoto N., Saito I.
      PLoS One. 2019 Apr 3;14(4):e0214495. doi: 10.1371/journal.pone.0214495. eCollection 2019.

    11. Study on the salivation effect of encapsulated food products containing Sichuan pepper oil
      Ryo K., Kaneko M., Takahashi K., Ono H., Ogasawara T., Abe M., Saito I.
      Clin. Exp. Dent. Res. 2019 Jan 31;5(1):7-13. doi: 10.1002/cre2.149. eCollection 2019 Feb.

    12. Generation of orthotopically functional salivary gland from embryonic stem cells
      Tanaka J., Ogawa M., Hojo H., Kawashima Y., Mabuchi Y., Hata K., Nakamura S., Yasuhara R., Takamatsu K., Irié T., Fukada T., Sakai T., Inoue T., Nishimura R., Ohara O., Saito I., Ohba S., Tsuji T., and Mishima K.
      Nature Commun. 2018. Oct 11;9(1):4216. doi: 10.1038/s41467-018-06469-7.

    13. Clinical practice guideline for Sjögren’s syndrome 2017
      Sumida T., Azuma N., Moriyama M., Takahashi H., Asashima H., Honda F., Abe S., Ono Y., Hirota T., Hidrata S., Tanaka Y., Shimizu T., Nakamura H., Kawakami A., Sano H., Ogawa Y., Tsubota K., Ryo K., Saito I., Tanaka A., Nakamura S., Takamura E., Tanaka M., Suzuki K., Takeuchi T., Yamakawa N., Mimori T., Ohta A., Nishiyama S., Yoshihara T., Suzuki Y., Kawano M., Tomiita M., Tsuboi H.
      Mod. Rheumatol. 2018 Feb 7:1-74. doi: 10.1080/14397595.2018.1438093. [Epub ahead of print].

    14. Effects of Singing on Oral Function, Stress, and Immunity
      Sakano K., Ryo K., Tamaki Y., Nakayama R., Ebihara S., Tozuka K., Saito I.
      Oral Health and Care., 2018. 2(5):1-6. doi:10.15761/OHC.1000135.

    15. The Candida species that are important for the development of atrophic glossitis in xerostomia patients
      Nakamura S., Okamoto M.R., Yamamoto K., Tsurumoto A., Yoshiko Y., Iwabuchi H., Saito I., Maeda N., Nakagawa Y.
      BMC Oral Health., 2017. Dec 16;17(1):153. doi: 10.1186/s12903-017-0449-3.

    16. Salivary Gland derived BDNF Overexpression in Mice Exerts an Anxiolytic Effect
      Saruta J., To M., Sugimoto M., Yamamoto Y., Shimizu T., Nakagawa Y., Inoue H., Saito I., Tsukinoki K.
      Int. J. Mol. Sci., 2017. 18(9), 1902; doi: 10.3390/ijms18091902.

    17. Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjögren’s syndrome with other sets of criteria in Japanese patients
      Tsuboi H., Hagiwara S., Asashima H., Takahashi H., Harota T., Noma H., Umehara H., Kawakami A., Nakamura H., Sano H., Tsubota K., Ozawa Y., Takamura E., Saito I., Inoue H., Nakamura S., Moriyama M., Takeuchi T., Tanaka Y., Hirata S., Mimori T., Matsumoto I., Sumida T.
      Ann. Rheum. Dis., 2017. Mar 22. DOI: 10.1136/annrheumdis-2016-210758.

    18. Resveratrol improves salivary dysfunction in a non-obese diabetic (NOD) mouse model of Sjögren’s syndrome
      Inoue H., Kishimoto A., Ushikoshi-Nakayama R., Hasaka A., Takahashi A., Ryo K., Muramatsu T., Ide F., Mishima K., Saito I.
      J.Clin. Biochem. Nutr. 2016. 59(2): 107-112.doi: 10.3164/jcbn.16-31.

    19. Sex-Based Differences in Smgc Expression in the Submandibular Gland of C57BL/6 Mice
      Kusakabe Y., Shindo Y., Kawai T., Takahashi Y., Koori M., Inoue H., Saito I.
      Pathobiology, 2016. 83(6): 287–294. doi: 10.1159/000446000. Pub 2016 Jun 2.

    20. Anticentromere antibody-positive primary Sjögren's syndrome: Epitope analysis of a subset of anticentromere antibody-positive patients
      Tanaka N., Muro Y., Suzuki Y., Nishiyama S., Takada K., Sekiguchi M., Hashimoto N., Ohmura K., Shimoyama K., Saito I., Kawano M., Akiyama M.
      Mod. Rheumatol., 2016 May 10:1-7. DOI: 10.1080/14397595. 2016.1176327.

    21. Evaluation of the effects of quercetin on damaged salivary secretion
      Takahashi A., Inoue H., Mishima K., Ide F., Nakayama R., Hasaka A., Ryo K., Ito Y., Sakurai T., Hasegawa Y., Saito I.
      PLoS One, 2015 Jan 28;10(1): e0116008. doi: 10.1371/journal.pone.0116008. eCollection 2015.

    22. The effect of cognitive appraisal for stressors on the oral health-related QOL of dry mouth patients
      Matsuoka H., Chiba I., Sakano Y., Saito I., Abiko Y.
      Biopsychosoc Med., 2014 Oct 22;8:24. doi: 10.1186/1751-0759-8-24. eCollection 2014.

    23. Therapeutic effects of isoflavones on impaired salivary secretion
      Ryo K., Takahashi A., Nimi A., Tamaki Y., Ohnishi-Kameyama M., Inoue H., Saito I.
      J. Clin. Biochem. Nutr., 55(3): 168-173, Sep, 30, 2014. doi: 10.3164/jcbn.14-49. Epub Sep, 30, 2014.

    24. Efficient diagnosis of Sjögren's syndrome to reduce the burden on patients
      Niikura A.J., Yamachika S., Yamamoto K., Okamoto M.R., Ikeda Y. F., Nakamura S., Oda E., Imamura T.K., Saito I., Nakagawa Y.
      Mod. Rheumatol. 25(1): 100-104, Jan. 2014. doi: 10.3109/14397595.2014.927969. Epub Jun, 12, 2014.

    25. Possible benefits of singing to the mental and physical condition of the elderly
      Sakano K., Ryo K., Tamaki Y., Nakayama R., Hasaka A., Takahashi A., Ebihara S., Tozuka K., Saito I.
      Biopsychosoc. Med., 8: 11. May 21, 2014. doi: 10.1186/1751-0759-8-11. eCollection 2014.

    26. Primary and secondary surveys on epidemiology of Sjogren’s syndrome in Japan
      Tsuboi H., Asashima H., Takai C., Hagiwara S., Hagiya C., Yokosawa M., Hirota T., Umehara H., Kawakami A., Nakamura H., Sano H., Tsubota K., OgawaY., Takamura E., Saito I., Inoue H., Nakamura S., Moriyama M., Takeuchi T., Tanaka Y., Hirata S., Mimori T., Yoshifuji H., Ohta A., Matsumoto I., Sumida T.
      Mod. Rheumatol., 24(3): 464-470. May 2014. doi: 10. 3109/14397595. 843765. Epub 2013.

    27. Factors associated with the presence of atrophic tongue in patients with dry mouth
      Kimori H., Yamamoto K., Yamachika S., Tsurumoto A., Kamikawa Y., Sasao M., Morito M., Saito I., Ohshima T., Maeda N., Nakagawa Y.
      Gerodontology, 32(1): 13-17. Mar, 30, 2015. doi: 10.1111/ger.12045. Epub ahead of print May 30, 2015.

    28. Validation of different sets of criteria for the diagnosis of Sjogren's syndrome in Japanese patients
      Tsuboi H., Hagiwara S., Asashima H., Umehara H., Kawakami A., Nakamura H., Sano H., Tsubota K., Ogawa Y., Takamura E., Saito I., Inoue H., Nakamura S., Moriyama M., Takeuchi T., Tanaka Y., Hirata S., Mimori T., Matsumoto I., Sumida T.
      Mod. Rheumatol., 23(2): 219-225, 2013. doi: 10.1007/s10165-012-0812-9. Epub Dec, 28, 2012.

    29. Transplantation of side population cells restores the function of damaged exocrine glands through clusterin
      Mishima K., Inoue H., Nishiyama T., Mabuchi Y., Amano Y., Ide F., Matsui M., Yamada H., Yamamoto G., Tanaka J., Yasuhara R., Sakurai T., Lee M., Chiba K., Sumimoto H., Kawakami Y., Matsuzaki Y., Tsubota K., Saito I.
      Stem Cells, 30(9): 1925-1937, Sep, 2012. doi10.1002/stem.1173 Aug, 20, 2012.

    30. Efficacy of Fungiflora Y staining for the diagnosis of oral erythematous candidiasis
      Okamoto M.R., Kamoi M., Yamachika S., Tsurumoto A., Imamura T., Yamamoto K., Kadomatsu S., Saito I., Maeda N., Nakagawa Y.
      Gerodontology, 30(3): 220-225, Sep. 2013. doi:10.1111/j.1741-2358.2012.00668.x. Epub May 14, 2012.

    31. Characterization of cultivated murine lacrimal gland epithelial cells
      Kobayashi S., Kawakita T., Kawashima M., Okada N., Mishima K., Saito I., Ito M., Shimmura S., Tsubota K.
      Mol. Vis., 18: 1271-1277, May 12, 2012. doi:10.3109/00016489.2012.657358. Epub May 12, 2012.

    32. Aryl hydrocarbon receptor-mediated induction of Epstein-Barr virus reactivation as a risk factor for Sjogren’s syndrome
      Inoue H., Mishima K., Yamamoto S., Nakayama R., Nakagawa Y., Yamamoto K., Ryo K., Ide F., Saito I.
      J. Immunol., 188(9): 4654-4662, May 1, 2012. doi: 10.4049/jimmunol.1101575. Epub Mar 30, 2012.

    33. Effects of Coenzyme Q10 on salivary secretion
      Ryo K., Ito A., Takatori R., Tai Y., Arikawa K., Seido T., Yamada T., Shinpo K., Tamaki Y., Fujii K., Yamamoto Y., Saito I.
      Clin. Biochem., 44(8-9): 669-674, 2011. doi: 10.1016/j.clinbiochem.2011.03.029. Epub Mar, 22, 2011.

    34. Evaluation of therapeutic effects of astaxanthin on impairments in salivary secretion
      Yamada T., Ryo K., Tai Y., Tamaki Y., Inoue H., Mishima K., Tsubota K., Saito I.
      J. Clin. Biochem. Nutr., 47(2): 130-137, Sep, 2010. doi: 10.3164/jcbn.10-31. Epub Jun, 22, 2010.

    35. The role of fractalkine as an accelerating factor on the autoimmune exocrinopathy in mice. Invest
      Tsubota K., Nishiyama T., Mishima K., Inoue H., Doi T., Tsunenari Y., Hattori Y., Kodama T., Higuchi A., Hayashi Y., Saito I.
      Ophthalmol. Vis. Sci., 50(10): 4753-4760, Oct, 2009. doi: 10.1167/iovs.08-2596. Epub Apr, 30, 2009.

    36. Protective effect of lecithinized SOD on reactive oxygen species-induced xerostomia
      Tai Y., Inoue H., Sakurai T., Yamada H., Morito M., Ide F., Mishima K., Saito I.
      Radiat. Res., 172(3): 331-338, Sep, 2009. doi: 10.1667/RR1557.1.

    37. The application of a night guard for sleep-related xerostomia
      Yamamoto K., Nagashima H., Yamachika S., Hoshiba D., Yamaguchi K., Yamada H., Saito I., Nakagawa Y.
      Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2008 Sep;106(3):e11-4. doi: 10.1016/j.tripleo.2008.05.015.

    38. Tear cytokine and ocular surface alterations following brief passive cigarette smoke exposure
      Rummenie V. T., Matsumoto Y., Dogru M., Wang Y., Hu Y., Ward S. K., Igarashi A., Wakamatsu T., Ibrahim O., Goto E., Luyten G., Inoue H., Saito I., Shimazaki J., Tsubota K.
      Cytokine, 43(2): 200-208, Aug, 2008. doi: 10.1016/j.cyto.2008.05.011. Epub Jul, 3, 2008.

    39. Alterations of the tear film and ocular surface health in chronic smokers
      Matsumoto Y., Dogru M., Goto E., Sasaki Y., Inoue H., Saito I., Shimazaki J., Tsubota K.
      Eye, 22(7): 961-968, Jul, 2008. doi: 10.1038/eye.2008.78. Epub Apr, 18, 2008.

    40. Amelioration of lacrimal gland inflammation by oral administration of K-13182 in Sjogren's syndrome model mice
      Nishiyama T., Mishima K., Obara K., Inoue H., Doi T., Kondo S., Saka M., Tabunoki Y., Hattori Y., Kodama T., Tsubota K., Saito I.
      Clin. Exp. Immunol., 149(3): 586-595, Sep, 2007. doi:10.1111/j.1365-2249.2007.03448.x Epub Jul, 5, 2007.

    41. Efficacy prediction of cevimeline in patients with Sjogren's syndrome
      Yamada H., Nakagawa Y., Wakamatsu E., Sumida T., Yamachika S., Nomura Y., Mishima K., Saito I.
      Clin. Rheumatol., 26(8): 1320-1327, Aug, 2007. doi:10.1007/s10067-006-0507-8 Epub Jan, 13, 2007.

    42. Up-regulated PAR-2-mediated salivary secretion in mice deficient in muscarinic acetylcholine receptor subtypes
      Nishiyama T., Nakamura T., Obara K., Inoue H., Mishima K., Matsumoto N., Matsui M., Manabe T., Mikoshiba K., Saito I.
      J. Pharmacol. Exp. Ther., 320(2): 516-524, Feb, 2006. doi: 10.1124/jpet.106.113092 Epub Oct, 31, 2006.

    43. Possible involvement of oxidative stress in salivary gland of patients with Sjogren's syndrome
      Ryo K., Yamada H., Nakagawa Y., Tai Y., Obara K., Inoue H., Mishima K., Saito I.
      Pathobiology, 73(5): 252-260, 2006. doi:10.1159/000098211

    44. Involvement of cAMP response element-binding protein activation in salivary secretion
      Yamada K., Inoue H., Kida S., Masushige S., Nishiyama T., Mishima K., Saito I.
      Pathobiology, 73(1): 1-7, Jun, 2006. doi:10.1159/000093086

    45. Novel role for RbAp48 in tissue-specific, estrogen deficiency-dependent apoptosis in the exocrine glands
      Ishimaru N., Arakaki R., Omotehara F., Yamada K., Mishima K., Saito I., Hayashi Y.
      Mol. Cell Biol., 26(8): 2924-2935, Apr, 2006. doi:10.1128/MCB.

    46. Preliminary results of moisture checker for Mucus in diagnosing dry mouth
      Yamada H., Nakagawa Y., Nomura Y., Yamamoto K., Suzuki M., Watanabe N.Y., Saito I., Seto K.
      Oral Dis., 11(6): 405-407, Nov, 2005. doi:10.1111/j.1601-0825.2005.01136.x Epub Nov, 1, 2007.

    47. Molecular analysis of the human autoantibody response to alpha-fodrin in Sjogren's syndrome reveals novel apoptosis-induced specificity
      Maruyama T., Saito I., Hayashi Y., Kompfner E., Fox R. I., Burton D. R., Ditzel H. J.
      Am. J. Pathol., 165(1): 53-61, Jul, 2004.

    48. Activation of Epstein-Barr virus by saliva from Sjogren's syndrome patients
      Nagata Y., Inoue H., Yamada K., Higashiyama H., Mishima K., Kizu Y., Takeda I., Mizuno F., Hayashi Y., Saito I.
      Immunology, 111(2): 223-229, Feb, 2004. doi: 10.1111/j.0019-2805.2003.01795.x Epub Jan, 21, 2004.

    49. Development of autoimmune exocrinopathy resembling Sjogren's syndrome in adoptively transferred mice with autoreactive CD4+ T cells
      Arakaki R., Ishimaru N., Saito I., Kobayashi M., Yasui N., Sumida T., Hayashi Y.
      Arthritis Rheum., 48(12): 3603-3609, Dec, 2003. doi:10.1002/art.11352 Epub Dec, 8, 2003.

    50. Possible role of nitric oxide in radiation-induced salivary gland dysfunction
      Takeda I., Kizu Y., Yoshitaka O., Saito I., Yamane G. Y.
      Radiat.Res., 159(4): 465-470, Apr, 2003.

    51. Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity
      Saegusa K., Ishimaru N., Yanagi K., Arakaki R., Ogawa K., Saito I., Katsunuma N., Hayashi Y.
      J. Clin. Invest., 110(3): 361-369, Aug, 2002. doi: 10.1172/JCI14682 Epub Aug, 1, 2002.

    52. Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjogren's syndrome
      Saegusa K., Ishimaru N., Yanagi K., Mishima K., Arakaki R., Suda T., Saito I., Hayashi Y.
      J. Immunol., 169(2): 1050-1057, Jul, 15, 2002. doi: 10.4049/ jimmunol.169.2.1050.

    53. Immunological characteristics of patients with vernal keratoconjunctivitis
      Fujishima H., Saito I., Takeuchi T., Tsubota K.
      Jpn. J. Ophthalmol., 46(3): 244-248, May-Jun, 2002.

    54. Possible role of organ-specific autoantigen for fas ligand-mediated activation-induced cell death in murine Sjogren's syndrome
      Ishimaru N., Yanagi K., Ogawa K., Suda T., Saito I., Hayashi Y.
      J. Immunol., 167(10): 6031-6037, Nov, 15, 2001. doi: 10.4049/ jimmunol.167.10.6031

    55. Possible involvement of Epstein-Barr virus mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome
      Inoue H., Tsubota K., Ono M., Kizu Y., Mizuno F., Takada K., Yamada K., Yanagi K., Hayashi Y., Saito I.
      J. Immunol., 166(9): 5801-5809, May 1, 2001. doi: 10.4049/ jimmunol.166.9.5801

    56. Improvement of lacrimal function by topical application of CyA in murine models of Sjogren's syndrome
      Tsubota K., Fujita H., Tadano K., Takeuchi T., Murakami T., Saito I., Hayashi Y.
      Invest. Ophthalmol. Vis. Sci., 42(1): 101-110, Jan, 2001.

    57. Combined medical and surgical treatment of severe vernal keratoconjunctivitis
      Fujishima H., Fukagawa K., Satake Y., Saito I., Shimazaki J., Takano Y., Tsubota K.
      Jpn. J. Ophthalmol., 44: 511-515, 2000.

    58. Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjögren's syndrome
      Saegusa K., Ishimaru N., Yanagi K., Haneji N., Nishino M., Azuma M., Saito I., Hayashi Y.
      J. Immunol., 165: 2251-2257, 2000.

    59. Mechanisms of neonatal tolerance induced in an animal model for primary Sjögren's syndrome by intravenous administration of autoantigen
      Saegusa K., Ishimaru N., Haneji N., Yanagi K., Yoneda T., Saito I., Hayashi Y.
      Scand. J. Immunol., 52: 264-270, 2000.

    60. Severe destructive autoimmune lesions with aging in murine Sjögren's syndrome through Fas-mediated apoptosis
      Ishimaru N., Yoneda T., Saegusa K., Yanagi K., Haneji N., Moriyama K., Saito I., Hayashi Y.
      Am. J. Pathol., 156: 1557-1564, 2000.

    61. Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjögren's syndrome (SS) through up-regulated Th2 response
      Saegusa K., Ishimaru N., Yanagi K., Haneji N., Nishino M., Azuma M., Saito I., Hayashi Y.
      Clin. Exp. Immunol., 119: 354-360, 2000.

    62. Possible involvement of IL-12 expression by Epstein-Barr virus in Sjögren's syndrome
      Horiuchi M., Yamano S., Inoue H., Ishii J., Nagata Y., Adachi H., Ono M., Renard JN., Mizuno F., Hayashi Y., Saito I.
      J. Clin. Pathol., 52: 833-837, 1999.

    63. Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjögren's syndrome through Fas-mediated apoptosis
      Ishimaru N., Saegusa K., Yanagi K., Haneji N., Saito I., Hayashi Y.
      Am. J. Pathol., 155: 173-181, 1999.

    64. Regulation of human leukocyte antigen expression in human conjunctival epithelium
      Tsubota K., Fukagawa K., Fujihara T., Shimmura S., Saito I., Saito K., Takeuchi T.
      Invest. Ophthalmol. Vis. Sci., 40: 28-34, 1999.

    65. Treatment of dry eye by autologous serum application in Sjögren's syndrome
      Tsubota K., Goto E., Fujita H., Ono M., Inoue H., Saito I., Shimmura S.
      Br. J. Ophthalmol., 83: 390-395, 1999.

    66. Fas ligand-mediated exocrinopathy resembling Sjögren's syndrome in mice transgenic for IL-10
      Saito I., Haruta K., Shimuta M., Inoue H., Sakurai H., Yamada K., Ishimaru N., Higashiyama H., Sumida T., Ishida H., Suda T., Noda T., Hayashi Y., Tsubota K.
      J. Immunol., 162: 2488-2494, 1999.

    67. Adenovirus-mediated gene transfer to the ocular surface epithelium
      Tsubota K., Inoue H., Ando K., Ono M., Yoshino K., Saito I.
      Exp. Eye Res., 67: 531-538, 1998.

    68. Anti-120-kDa alpha-fodrin immune response with Th1-cytokine profile in the NOD mouse model of Sjögren's syndrome
      Yanagi K., Ishimaru N., Haneji N., Saegusa K., Saito I., Hayashi Y.
      Eur. J. Immunol., 28: 3336-3345, 1998.

    69. Use of topical cyclosporin A in a primary Sjögren's syndrome mouse model
      Tsubota K., Saito I., Ishimaru N., Hayashi Y.
      Invest. Ophthalmol. Vis. Sci., 39: 1551-1559, 1998.

    70. Analysis of T cell receptor Vbeta usage in the autoimmune sialadenitis of non-obese diabetic(NOD) mice
      Yanagi K., Haneji N., Ishimaru N., Hamano H., Saito I., Hayashi Y.
      Clin. Exp. Immunol., 110: 440-446, 1997.

    71. Augmented expression of CD44 splice variants in lymphoproliferative disorder of the lacrimal gland in Sjögren's syndrome
      Hiraoka M., Saito I., Tsubota K., Sugai S., Miyasaka N.
      Jpn. J. Opthalmol., 41: 312-318, 1997.

    72. High incidence of autoimmune dacryoadenitis in male non-obese diabetic(NOD) mice depending on sex steroid
      Takahashi M., Ishimaru N., Yanagi K., Haneji N., Saito I., Hayashi Y.
      Clin. Exp. Immunol., 109: 555-561, 1997.

    73. Characterization of cytokine mRNA transcripts in conjunctival cells in patients with allergic conjunctivitis
      Fujishima H., Saito I., Takeuchi T., Shinozaki N., Tsubota K.
      Invest. Ophthalmol. Vis. Sci., 38: 1350-1357, 1997.

    74. Elevated levels of substance P in tears of patients with allergic conjunctivitis and vernal keratoconjunctivitis
      Fujishima H., Takeyama M., Takeuchi T., Saito I., Tsubota K.
      Clin. Exp. Allergy, 27: 372-378, 1997.

    75. Identification of alpha-fodrin as a candidate autoantigen in primary Sjögren's syndrome
      Haneji N., Nakamura T., Takio K., Yanagi K., Higashiyama H., Saito I., Noji S., Sugino H., Hayashi Y.
      Science, 276: 604-607, 1997.

    76. Retrovirus in salivary glands from patients with Sjögren's syndrome
      Yamano S., Renard JN., Mizuno F., Narita Y., Uchida Y., Higashiyama H., Sakurai H., Saito I.
      J. Clin. Pathol., 50: 223-230, 1997.

    77. Immunohistological analysis of tumour growth factor beta1 expression in normal and inflamed salivary glands
      Kizu Y., Sakurai H., Katagiri S., Shinozaki N., Ono M., Tsubota K., Saito I.
      J. Clin. Pathol., 49: 728-732, 1996.

    78. Increased expression of human thioredoxin/adult T cell leukemia-derived factor in Sjogren's syndrome
      Saito I., Shimuta M., Terauchi K., Tsubota K., Yodoi J., Miyasaka N.
      Arthritis Rheum., 39: 773-782, 1996.

    79. Increased levels of Epstein-Barr virus DNA in lacrimal glands of Sjögren's syndrome patients
      Tsubota K., Fujishima H., Toda I., Katagiri S., Kawashima Y., Saito I.
      Acta Ophtalmol. Scand., 73: 425-430, 1995.

    80. Diverse T cell receptor beta gene usage by infiltrating T cells in the lacrimal glands of Sjögren's syndrome
      Mizushima N., Kohsaka H., Tsubota K., Saito I., Miyasaka N.
      Clin. Exp. Immunol., 101: 33-38, 1995.

    81. Distribution of IgA1- and IgA-2 containing cells in lacrimal glands of patients with Sjogren's syndrome
      Ono M., Saito I., Yoshino K., Tsubota K., Moro I.
      Reg. Immunol., 6: 218-224, 1994.

    82. Rearrangement of the rheumatoid factor-related germline gene Vg and bcl-2 expression in lymphoproliferative disorders in patients with Sjögren's syndrome
      Sugai S., Saito I., Masaki Y., Takeshita S., Shimizu S., Tachibana J., Miyasaka N.
      Clin. Immunol. Immunopathol., 72:181-186, 1994.

    83. Possible involvement of Epstein- Barr virus in the pathogenesis of Sjogren's syndrome
      Miyasaka N., Saito I., Haruta J.
      Clin. Immunol. Immunopathol., 72:166-170. 1994.

    84. Spontaneous production of Epstein-Barr virus by B lymphoblastoid cell lines obtained from patients with Sjögren's syndrome. Possible involvement of a novel strain of Epstein-Barr virus in disease pathogenesis
      Tateishi M., Saito I., Yamamoto K., Miyasaka N.
      Arthritis Rheum., 36: 827-835, 1993.

    85. Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with Primary Sjögren's syndrome
      Kang HI., Fei HM., Saito I., Sawada S., Chen SL., Yi D., Chan E., Peebles C., Bugawan TL., Erlich HA., et al.
      J. Immunol., 150: 3615-3623, 1993.

    86. Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjogren's syndrome
      Saito I., Terauchi K., Shimuta M., Nishiimura S., Yoshino K., Takeuchi T., Tsubota K., Miyasaka N.
      J. Clin. Lab. Anal. 7: 180-187, 1993.

    87. Detection of Epstein-Barr virus and human herpes virus type 6 in saliva from patients with lymphoproliferative diseases by the polymerase chain reaction
      Saito I., Nishimura S., Kudo I., Fox RI., Moro I.
      Arch. Oral Biol., 36: 779-784, 1991.

    88. Detection of Epstein-Barr virus DNA by polymerase chain reaction in blood and tissue biopsies from patients with Sjogren's syndrome
      Saito I., Servenius B., Compton T., Fox RI.
      J. Exp. Med., 169: 2191-2198, 1989.

    89. Viral genomes in lymphomas of patients with Sjögren's syndrome Fox
      RI., Saito I., Chan EK, Josephs S., Salahuddin SZ., Ahlashi DV., Staal FW., Gallo R., Pei-Ping H., Le CS.
      J. Autoimmun., 2: 449-455, 1989.

    90. Immunohistochemical characterization of functional markers in human minor salivary gland tumors
      Saito I., Teratani K., Inoue M., Saito A., Funatsu K., Moro I.
      J. Oral Pathol., 13: 525-534, 1984.